Radiation therapy (RT) combined with CTLA4 blockers converts immunosuppressed (cold) mouse triple negative breast cancers (TNBCs) into immune infiltrated (hot) lesions. We have recently shown that targeting the myeloid compartment to improve dendritic cell activation is required for most TNBC-bearing mice to achieve superior therapeutic responses to RT plus CTLA4 inhibitors.
Keywords: CD8 T cells; In situ vaccination; T cell receptor; dendritic cells; draining lymph node; immune checkpoint inhibitors.
© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.