CD40 agonism improves anti-tumor T cell priming induced by the combination of radiation therapy plus CTLA4 inhibition and enhances tumor response

Oncoimmunology. 2023 Sep 15;12(1):2258011. doi: 10.1080/2162402X.2023.2258011. eCollection 2023.

Abstract

Radiation therapy (RT) combined with CTLA4 blockers converts immunosuppressed (cold) mouse triple negative breast cancers (TNBCs) into immune infiltrated (hot) lesions. We have recently shown that targeting the myeloid compartment to improve dendritic cell activation is required for most TNBC-bearing mice to achieve superior therapeutic responses to RT plus CTLA4 inhibitors.

Keywords: CD8 T cells; In situ vaccination; T cell receptor; dendritic cells; draining lymph node; immune checkpoint inhibitors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CTLA-4 Antigen
  • Humans
  • Immune Checkpoint Inhibitors*
  • Mice
  • T-Lymphocytes
  • Triple Negative Breast Neoplasms* / drug therapy
  • Triple Negative Breast Neoplasms* / radiotherapy

Substances

  • CTLA-4 Antigen
  • Immune Checkpoint Inhibitors
  • CTLA4 protein, human