Serum iron fluctuations link ferroptosis process with mortality and prognosis of acute pancreatitis

Yueling Deng; Tao Jiang; Jinhao Li; Pingping Yu; Ying Mei; Maojun Li; Xiaoya Qi; Fuyao Liu

doi:10.1016/j.isci.2023.107774

Serum iron fluctuations link ferroptosis process with mortality and prognosis of acute pancreatitis

iScience. 2023 Aug 29;26(10):107774. doi: 10.1016/j.isci.2023.107774. eCollection 2023 Oct 20.

Authors

Yueling Deng¹, Tao Jiang¹, Jinhao Li², Pingping Yu¹, Ying Mei¹, Maojun Li³, Xiaoya Qi¹, Fuyao Liu^{2

4}

Affiliations

¹ Health Management Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
² Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
³ Linshui County People Hospital, Guangan, Sichuan, China.
⁴ Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

Recently, the existence of ferroptosis has been confirmed in chronic pancreatitis. However, its role in acute pancreatitis (AP) process, especially in critical status, has not yet been mentioned. To verify this hypothesis, we included 873 AP patients (training set) and 1,188 NAFLD patients (internal validation set) selected from MIMIC-III (Medical Information Mark for Intensive Care) database and 218 AP patients (external validation set) in Linshui County People's Hospital ICU data. We analyzed the correlation between mortality and ferroptosis associating factors (such as serum iron, ALP, lactate, etc.) in them through regression analysis. In addition, to test the significance of these factors, the nomogram, AUC, and DCA analysis were applied. The results showed that serum iron, IBC, ALP, and lactate (p < 0.05) were independent factors for the mortality and prognosis of these patients. These correlations suggest ferroptosis and follow-up cell programmed death may own an important clinical interference significance among this population.

Keywords: Association analysis; Patient characteristics; Risk factor.