Algae: A Robust Living Material Against Cancer

Int J Nanomedicine. 2023 Sep 14:18:5243-5264. doi: 10.2147/IJN.S423412. eCollection 2023.

Abstract

Cancer is the second leading cause of death worldwide. Its incidence has been increasing in recent years, and it is becoming a major threat to human health. Conventional cancer treatment strategies, including surgery, chemotherapy, and radiotherapy, have faced problems such as drug resistance, toxic side effects and unsatisfactory therapeutic efficacy. Therefore, better development and utilization of biomaterials can improve the specificity and efficacy of tumor therapy. Algae, as a novel living material, possesses good biocompatibility. Although some reviews have elucidated several algae-based biomaterials for cancer treatment, the majority of the literature has focused on a limited number of algae. As a result, there is currently a lack of comprehensive reviews on the subject of anticancer algae. This review aims to address this gap by conducting a thorough examination of algal species that show potential for anticancer activity. Furthermore, our review will also elucidate the engineering strategies of algae and discuss the challenges and prospects associated with their implementation.

Keywords: algae; anticancer mechanism; biomaterials; engineering strategies; neoplasms.

Publication types

  • Review

MeSH terms

  • Biocompatible Materials
  • Drug-Related Side Effects and Adverse Reactions*
  • Humans
  • Neoplasms* / drug therapy

Substances

  • Biocompatible Materials

Grants and funding

This work was supported by the National Natural Science Foundation of China [82072051, 81771964].