Streptococcus gallolyticus Subspecies p asteurianus Meningitis in an Infant with Hypothyroidism and Diarrhea

Jianhui Li; Chongbing Yan; Dong Wei; Xiaohui Gong

doi:10.2147/IDR.S425637

Streptococcus gallolyticus Subspecies p asteurianus Meningitis in an Infant with Hypothyroidism and Diarrhea

Infect Drug Resist. 2023 Sep 14:16:6217-6223. doi: 10.2147/IDR.S425637. eCollection 2023.

Authors

Jianhui Li¹, Chongbing Yan¹, Dong Wei¹, Xiaohui Gong¹

Affiliation

¹ Department of Neonatology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, People's Republic of China.

Abstract

Streptococcus gallolyticus subspecies pasteurianus, formerly classified as S. bovis biotype II/2 until 2003, is a rare cause of infant meningitis. Over the past 2 decades, only a few individual case reports and limited case series exist in the English-language literature. Moreover, the pathogenesis of S. gallolyticus subsp. pasteurianus meningitis in infants is unclear. Here we report a case of meningitis in a 6-week-old infant with hypothyroidism and preceding diarrhea. In this case, S. gallolyticus was cultured from cerebrospinal fluid, and then S. gallolyticus subspecies pasteurianus was identified by metagenomic next-generation Sequencing. The infant recovered uneventfully after a 4-week antibiotic course with ceftriaxone and vancomycin. Then combined with the literature of S. gallolyticus subsp. pasteurianus meningitis in infants, we discuss the possible etiology.

Keywords: Streptococcus gallolyticus subsp. pasteurianus; diarrhea; hypothyroidism; infant; meningitis.

Publication types

Case Reports