First Report of Klebsiella subsp. Ozaenae Meningitis in Japan

Intern Med. 2023 Sep 15. doi: 10.2169/internalmedicine.1894-23. Online ahead of print.

Abstract

Although the frequency of community-acquired infections caused by Klebsiella pneumoniae subsp. ozaenae (K. ozaenae) is low, they are often detected in sputum specimens. In addition, lung abscesses, necrotizing pneumonia, and urinary tract infections caused by K. ozaenae have also been reported. We herein report the first detection of K. ozaenae as an etiological agent of bacterial meningitis in Japan. Cases of K. ozaenae meningitis complicated by diabetes mellitus and sinusitis have been reported elsewhere. When Klebsiella pneumoniae is detected in such cases, it is important to use other detection methods in addition to mass spectrometry for correct identification.

Keywords: Klebsiella pneumoniae; Klebsiella pneumoniae subsp. ozaenae; mass spectrometry; meningitis; sinusitis; whole genome sequencing.