Binding modes of high stoichiometry guest complexes with a Co8L12 cage uncovered by mass spectrometry

Daniel L Stares; Cristina Mozaceanu; Michael D Ward; Christoph A Schalley

doi:10.1039/d3cc04291j

Binding modes of high stoichiometry guest complexes with a Co₈L₁₂ cage uncovered by mass spectrometry

Chem Commun (Camb). 2023 Oct 4;59(79):11811-11814. doi: 10.1039/d3cc04291j.

Authors

Daniel L Stares¹, Cristina Mozaceanu², Michael D Ward², Christoph A Schalley¹

Affiliations

¹ Institut für Chemie und Biochemie, Freie Universität Berlin, Arnimallee 20, Berlin, 14195, Germany. c.schalley@fu-berlin.de.
² Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. m.d.ward@warwick.ac.uk.

PMID: 37721711
DOI: 10.1039/d3cc04291j

Abstract

We demonstrate how different modes of guest binding with a Co₈L₁₂ cubic cage can be determined using ESI-MS. High stoichiometry guest binding was observed, with the guests preferentially binding externally, but internal guest inclusion was also seen at higher guest loading.