Microorganisms Detected in Intussusception Cases and Controls in Children <3 Years in South Africa From 2013 to 2017

Nicola Anne Page; Rembuluwani Netshikweta; Jacqueline E Tate; Shabir A Madhi; Umesh D Parashar; Michelle J Groome; South African Intussusception Surveillance Group

doi:10.1093/ofid/ofad458

Microorganisms Detected in Intussusception Cases and Controls in Children <3 Years in South Africa From 2013 to 2017

Open Forum Infect Dis. 2023 Sep 4;10(9):ofad458. doi: 10.1093/ofid/ofad458. eCollection 2023 Sep.

Authors

Nicola Anne Page^{1

2}, Rembuluwani Netshikweta¹, Jacqueline E Tate³, Shabir A Madhi⁴, Umesh D Parashar³, Michelle J Groome⁴; South African Intussusception Surveillance Group

Collaborators

South African Intussusception Surveillance Group:
Marion Arnold, Milind Chitnis, Sharon Cox, Corné de Vos, Mari Kirsten, Susanna M le Grange, Jerome Loveland, Sello Machaea, Ashwini Maharaj, Aletha Withers

Affiliations

¹ National Institute for Communicable Diseases, A Division of the National Health Laboratory Services, Johannesburg, South Africa.
² Department of Medical Virology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
³ Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
⁴ South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit (VIDA), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Abstract

A matched case-control evaluated infectious etiologies in children <3 years in post-rotavirus vaccine intussusception surveillance. Adenovirus and adenovirus types C, A, and B were detected more frequently in cases versus controls at statistically significant values. Wild-type rotavirus, rotavirus vaccine strains, and human herpesvirus were not associated with intussusception.

Keywords: adenovirus; etiology; intussusception; rotavirus; vaccination.