Research progress on the mechanism of cholesterol-25-hydroxylase in intestinal immunity

Guoqiang Zhong; Chengcheng He; Shanping Wang; Chuangzhen Lin; Mingsong Li

doi:10.3389/fimmu.2023.1241262

Research progress on the mechanism of cholesterol-25-hydroxylase in intestinal immunity

Front Immunol. 2023 Aug 31:14:1241262. doi: 10.3389/fimmu.2023.1241262. eCollection 2023.

Authors

Guoqiang Zhong¹, Chengcheng He¹, Shanping Wang¹, Chuangzhen Lin¹, Mingsong Li¹

Affiliation

¹ Inflammatory Bowel Diseases Research Center, Department of Gastroenterology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Abstract

Inflammatory bowel disease (IBD), a general term encompassing Crohn's disease (CD) and ulcerative colitis (UC), and other conditions, is a chronic and relapsing autoimmune disease that can occur in any part of the digestive tract. While the cause of IBD remains unclear, it is acknowledged that the disease has much to do with the dysregulation of intestinal immunity. In the intestinal immune regulatory system, Cholesterol-25-hydroxylase (CH25H) plays an important role in regulating the function of immune cells and lipid metabolism through catalyzing the oxidation of cholesterol into 25-hydroxycholesterol (25-HC). Specifically, CH25H focuses its mechanism of regulating the inflammatory response, signal transduction and cell migration on various types of immune cells by binding to relevant receptors, and the mechanism of regulating lipid metabolism and immune cell function via the transcription factor Sterol Regulator-Binding Protein. Based on this foundation, this article will review the function of CH25H in intestinal immunity, aiming to provide evidence for supporting the discovery of early diagnostic and treatment targets for IBD.

Keywords: 25-hydroxycholesterol; cholesterol-25-hydroxylase; inflammatory bowel disease; intestinal immunity; mechanism.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Colitis, Ulcerative*
Crohn Disease*
Humans
Inflammatory Bowel Diseases*
Intestines* / immunology

Substances

cholesterol 25-hydroxylase

Grants and funding

This work was supported by the National Natural Science Foundation of China (grant number 82204480 and 82070565) and Guangdong Basic and Applied Basic Research Foundation (grant number 2021A1515110714).