Subacromial injection of hydrolyzed collagen in the symptomatic treatment of rotator cuff tendinopathy: an observational multicentric prospective study on 71 patients

Matteo Buda; Sabri Dlimi; Marco Parisi; Andrea Benoni; Gianluca Bisinella; Stefano Di Fabio

doi:10.1016/j.jseint.2023.06.009

Subacromial injection of hydrolyzed collagen in the symptomatic treatment of rotator cuff tendinopathy: an observational multicentric prospective study on 71 patients

JSES Int. 2023 Jul 7;7(5):799-804. doi: 10.1016/j.jseint.2023.06.009. eCollection 2023 Sep.

Authors

Matteo Buda^{1

2}, Sabri Dlimi³, Marco Parisi⁴, Andrea Benoni⁵, Gianluca Bisinella¹, Stefano Di Fabio⁴

Affiliations

¹ Department of Orthopaedics and Trauma Surgery, Ospedali Riuniti Padova Sud, Monselice, (PD), Italy.
² Department of Orthopedics and Trauma Surgery Rizzoli-Argenta, Istituto Ortopedico Rizzoli, Argenta, (FE), Italy.
³ Department of Orthopaedics and Trauma Surgery, Poliambulatorio Arcella, Padova, Italy.
⁴ Department of Orthopaedics and Trauma Surgery, San Martino Hospital of Belluno, ULSS1 Dolomiti, Belluno, Italy.
⁵ Department of Orthopaedics and Trauma Surgery, University of Verona, Verona, Italy.

Abstract

Background: The purpose of the present observational multicentric prospective study was to evaluate the efficacy and safety of a new infiltration device (CHondroGrid, Bioteck S.p.A, Arcugnano, Italy) based on hydrolyzed collagen in the treatment of rotator cuff tendinopathy.

Methods: Seventy-one patients (53.3 ± 11.6 years old) affected by rotator cuff tendinopathy were treated in 2021 with two subacromial injections of CHondroGrid at 13 ± 2.9 days apart. The outcomes measured were the visual analog scale (VAS) score (in movement, during the night, and at rest), the Constant Score, the Simple Shoulder Test, and patient satisfaction. The outcome variables were measured before each injection, at 1 month and at 6 months after the last injection.

Results: The treatment was significantly effective from the first injection and up to the six-month follow-up. At the last follow-up, the VAS score on movement had improved by 71% (P < .001), while the VAS score at rest and during the night had ameliorated by 91% and 87%, respectively (P < .001). The Constant Score and Simple Shoulder Test improved by 32% and 61%, respectively (P < .001). No adverse events were reported.

Conclusions: CHondroGrid resulted in a safe and effective treatment in pain relief and for the functional recovery of rotator cuff tendinopathy.

Keywords: Hydrolyzed collagen; Infiltrative device; Non-pharmacological therapy; Rotator cuff; Tendinopathy; Tendons.