Whole Gamma Imaging: Challenges and Opportunities

Taiga Yamaya; Hideaki Tashima; Sodai Takyu; Miwako Takahashi

doi:10.1016/j.cpet.2023.08.003

Whole Gamma Imaging: Challenges and Opportunities

PET Clin. 2024 Jan;19(1):83-93. doi: 10.1016/j.cpet.2023.08.003. Epub 2023 Sep 15.

Authors

Taiga Yamaya¹, Hideaki Tashima², Sodai Takyu², Miwako Takahashi²

Affiliations

¹ Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. Electronic address: yamaya.taiga@qst.go.jp.
² Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

PMID: 37718218
DOI: 10.1016/j.cpet.2023.08.003

Abstract

Compton imaging has been recognized as a possible nuclear medicine imaging method following the establishment of SPECT and PET. Whole gamma imaging (WGI), a combination of PET and Compton imaging, could be the first practical method to bring out the potential of Compton imaging in nuclear medicine. With the use of such positron emitters as ⁸⁹Zr and ⁴⁴Sc, WGI may enable highly sensitive imaging of antibody drugs for early tumor detection and quantitative hypoxia imaging for effective tumor treatment. Some of these concepts have been demonstrated preliminarily in physics experiments and small animal imaging tests with a developed WGI prototype.

Keywords: Antibody; Compton camera; Multiple myeloma; PET; Positronium; WGI.

Publication types

Review

MeSH terms

Animals
Humans
Neoplasms* / diagnostic imaging
Nuclear Medicine*
Radionuclide Imaging
Radiopharmaceuticals
Tomography, Emission-Computed, Single-Photon / methods

Substances

Radiopharmaceuticals