Phosphoinositide 3-kinase as a therapeutic target in angiogenic disease

Wenyi Wu; Xiaobo Xia; Luosheng Tang; Jing Luo; Siqi Xiong; Gaoen Ma; Hetian Lei

doi:10.1016/j.exer.2023.109646

Phosphoinositide 3-kinase as a therapeutic target in angiogenic disease

Exp Eye Res. 2023 Nov:236:109646. doi: 10.1016/j.exer.2023.109646. Epub 2023 Sep 15.

Authors

Wenyi Wu¹, Xiaobo Xia², Luosheng Tang³, Jing Luo³, Siqi Xiong², Gaoen Ma⁴, Hetian Lei⁵

Affiliations

¹ Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Ophthalmology, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address: wenyi_wu@csu.edu.com.
² Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Ophthalmology, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
³ Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ Department of Ophthalmology, The First Affiliated Hospital of Hainan Medical University, Haikou, 571199, China. Electronic address: 15757826611@163.com.
⁵ Shenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen, China. Electronic address: leithetian18@hotmail.com.

PMID: 37716399
DOI: 10.1016/j.exer.2023.109646

Abstract

Phosphoinositide 3-kinases (PI3Ks) generate lipids that control multitudinous intracellular cell signaling events which participate in cell survival and proliferation. In addition, PI3K signaling also contributes to metabolism, immunity, angiogenesis and cardiovascular homeostasis, and many diseases. The diverse actions of PI3K stem from the existence of their various isoforms and a variety of protein effectors. Hence, PI3K isoform-specific inhibitors have already achieved a wonderful effect on treating cancer. Herein, we summarize the molecular mechanism of PI3K inhibitors in preventing the permeability of vessels and neovascularization. Additionally, we briefly illustrate how PI3K signaling modulates blood vessel growth and discuss the different roles that PI3K isoforms play in angiogenesis.

Keywords: Akt; Angiogenesis; Inflammation; Isoform inhibitors; PI3K.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Phosphatidylinositol 3-Kinase*
Phosphatidylinositol 3-Kinases* / metabolism
Phosphoinositide-3 Kinase Inhibitors / pharmacology
Protein Isoforms / metabolism
Signal Transduction

Substances

Phosphatidylinositol 3-Kinase
Phosphatidylinositol 3-Kinases
Phosphoinositide-3 Kinase Inhibitors
Protein Isoforms