Seizure-related stress and arousal responses mediate a relationship between anxiety trait and state in epilepsy

Hironobu Nakamura; Genichi Sugihara; Keiko Hara; Motoki Inaji; Masahiro Noha; Ichiro Takumi; Masako Watanabe; Hidehiko Takahashi; Taketoshi Maehara; Hitoshi Yamamoto; Shunsuke Takagi

doi:10.1016/j.yebeh.2023.109442

Seizure-related stress and arousal responses mediate a relationship between anxiety trait and state in epilepsy

Epilepsy Behav. 2023 Oct:147:109442. doi: 10.1016/j.yebeh.2023.109442. Epub 2023 Sep 14.

Authors

Affiliations

¹ Department of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan; Hara Clinic, Kanagawa, Japan.
² Department of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
³ Hara Clinic, Kanagawa, Japan; Department of Respiratory and Nervous System Science, Biomedical Laboratory Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
⁴ Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan.
⁵ Department of Neurosurgery, Okinawa Red Cross Hospital, Okinawa, Japan.
⁶ Department of Neurosurgery, St. Marianna University School of Medicine, Kanagawa, Japan.
⁷ Shinjuku Shinkei Clinic, Tokyo, Japan.
⁸ Department of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan; Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan.
⁹ Department of Pediatrics, St. Marianna University School of Medicine, Kanagawa, Japan.
¹⁰ Department of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan; Sleep Research Institute, Waseda University, 513 Waseda-Tsurumakicho, Shinjuku, Tokyo 162-0041 Japan. Electronic address: stakagi.psyc@tmd.ac.jp.

PMID: 37716325
DOI: 10.1016/j.yebeh.2023.109442

Abstract

Background: Epilepsy causes substantial psychological distress and anxiety, primarily due to seizures. However, the impact of stress responses and changes in arousal and their association with anxiety patterns in patients with epilepsy (PWE) remains unclear. This study aimed to investigate the relationships among seizures, stress and arousal characteristics, and trait and state anxiety characteristics in PWE.

Methods: Our sample consisted of 159 outpatients with epilepsy recruited from five institutions in Japan in 2020. Participants completed the State-Trait Anxiety Inventory-Form JYZ (STAI) and the Japanese-Stress Arousal Check List (J-SACL). We analyzed the correlations between inventory scores and clinical information. Using principal component analysis (PCA), we derived epilepsy-specific stress/arousal characteristics, which accounted for high arousal and low-stress levels, termed epilepsy-specific stress or arousal response (ESAR), from the J-SACL scores. We conducted a mediation analysis to assess the mediating role of ESAR in the relationship between traits and state anxiety.

Results: We found significant correlations between J-SACL stress and arousal factors (r = -0.845, p < 0.001), ESAR and seizure frequency (r = -0.29, p < 0.001), ESAR and trait anxiety scores on the STAI (r = -0.77, p < 0.0001), and ESAR and state anxiety scores on the STAI (r = -0.60, p < 0.0001). Mediation analysis supported by the Monte Carlo method revealed that ESAR significantly mediated the association between trait and state anxiety.

Conclusions: These findings elucidate the epilepsy-specific stress and arousal characteristics and their roles in mediating traits and state anxiety. These results may reflect the long-term clinical course and unique emotion recognition tendencies in epilepsy.

Keywords: Anxiety; Arousal; Seizure; State; Stress; Trait.