Extrinsic lipoid pneumonia due to chronic polyethylene glycol consumption: A case report

Respir Investig. 2023 Nov;61(6):768-772. doi: 10.1016/j.resinv.2023.08.002. Epub 2023 Sep 15.

Abstract

Extrinsic lipoid pneumonia (ELP) results from the aspiration of lipid-containing substances. Tissue or cell histopathology after Oil-Red-O staining can confirm the diagnosis, which requires proper tissue handling and preparation during bronchoscopy. Here, we report a case of ELP in a quadriplegic patient with a long history of dysphagia and polyethylene glycol consumption. Computed tomography (CT) of the chest revealed multiple, progressively enlarging, fat-attenuated, nodular pulmonary lesions. Bronchoscopy with bronchoalveolar lavage (BAL) and a transbronchial forceps biopsy confirmed the diagnosis of lipoid pneumonia. We discuss the clinical, radiological, and pathological features of ELP and highlight the preparatory steps required for obtaining a successful diagnosis.

Keywords: Foamy macrophages; Hounsfeld units; Lipoid pneumonia; Oil-Red-O; Polyethylene glycol.

Publication types

  • Case Reports

MeSH terms

  • Bronchoalveolar Lavage / methods
  • Humans
  • Lung / pathology
  • Mineral Oil
  • Pneumonia, Lipid* / chemically induced
  • Pneumonia, Lipid* / diagnostic imaging
  • Polyethylene Glycols / adverse effects

Substances

  • Polyethylene Glycols
  • Mineral Oil