Four new alkylamides from the fruits of Piper retrofractum and antityrosinase evaluation

Thita Yodsawad; Thitipan Meemongkolkiat; Chanpen Chanchao; Thanakorn Damsud; Preecha Phuwapraisirisan

doi:10.1080/14786419.2023.2258542

Four new alkylamides from the fruits of Piper retrofractum and antityrosinase evaluation

Nat Prod Res. 2023 Sep 15:1-10. doi: 10.1080/14786419.2023.2258542. Online ahead of print.

Authors

Thita Yodsawad¹, Thitipan Meemongkolkiat², Chanpen Chanchao², Thanakorn Damsud³, Preecha Phuwapraisirisan¹

Affiliations

¹ Center of Excellence in Natural Product, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
² Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
³ Faculty of Science and Technology, Rajamangala University of Technology Srivijaya, Nakhon Si Thammarat.

PMID: 37715311
DOI: 10.1080/14786419.2023.2258542

Abstract

Four new alkylamides named retroframides A-D (1-4) together with twenty-two known compounds were isolated from the fruits of Piper rectrofractum. The structures of new compounds were elucidated on the basis of spectroscopic data including 2D NMR and chemical derivatization followed by GC-MS analysis. Of isolated compounds, piperine (25) and pellitorine (26) revealed moderate inhibition against tyrosinase with percentage inhibition of 36.1 and 40.7.

Keywords: Alkylamide; antityrosinase; melanin; piper; piper rectrofractum.