The role of neutrophils in diabetic ulcers and targeting therapeutic strategies

Xiao-Xuan Ma; Qing-Kai Liu; Le Kuai; Xin Ma; Yue Luo; Ying Luo; Jian-Kun Song; Xiao-Ya Fei; Jing-Si Jiang; Ming-Xia Wang; Fang Shen; Yi Ru; Bin Li

doi:10.1016/j.intimp.2023.110861

The role of neutrophils in diabetic ulcers and targeting therapeutic strategies

Int Immunopharmacol. 2023 Nov;124(Pt A):110861. doi: 10.1016/j.intimp.2023.110861. Epub 2023 Sep 14.

Authors

Xiao-Xuan Ma¹, Qing-Kai Liu¹, Le Kuai¹, Xin Ma², Yue Luo³, Ying Luo¹, Jian-Kun Song³, Xiao-Ya Fei³, Jing-Si Jiang³, Ming-Xia Wang³, Fang Shen³, Yi Ru⁴, Bin Li⁵

Affiliations

¹ Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China.
² Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China.
³ Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China.
⁴ Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: 1356632788@qq.com.
⁵ Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China. Electronic address: 18930568129@163.com.

PMID: 37713783
DOI: 10.1016/j.intimp.2023.110861

Abstract

Diabetic ulcers (DUs) are a common complication of diabetes with high morbidity, poor prognosis, and a high socio-economic burden. The main pathological manifestations of DUs are chronic inflammation, impaired re-epithelialization, and impaired angiogenesis. During the inflammatory phase, neutrophils are one of the main DU cell types and act by releasing neutrophil extracellular traps (NETs), leading to poor healing in DUs. This review summarizes the role of neutrophils in the pathology and treatment of DUs, with a view to potential novel therapies and therapeutic targets.

Keywords: Diabetic ulcers; Neutrophil extracellular trap; Neutrophils; Wound healing.

Publication types

Review