BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism

Elife. 2023 Sep 15:12:RP88521. doi: 10.7554/eLife.88521.

Abstract

The rising prevalence of nonalcoholic fatty liver disease (NAFLD) has become a global health threat that needs to be addressed urgently. Basic leucine zipper ATF-like transcription factor (BATF) is commonly thought to be involved in immunity, but its effect on lipid metabolism is not clear. Here, we investigated the function of BATF in hepatic lipid metabolism. BATF alleviated high-fat diet (HFD)-induced hepatic steatosis and inhibited elevated programmed cell death protein (PD)1 expression induced by HFD. A mechanistic study confirmed that BATF regulated fat accumulation by inhibiting PD1 expression and promoting energy metabolism. PD1 antibodies alleviated hepatic lipid deposition. In conclusion, we identified the regulatory role of BATF in hepatic lipid metabolism and that PD1 is a target for alleviation of NAFLD. This study provides new insights into the relationship between BATF, PD1, and NAFLD.

Keywords: BATF; NAFLD; PD1; cell biology; immune; mouse.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies
  • Basic-Leucine Zipper Transcription Factors / genetics
  • Diet, High-Fat / adverse effects
  • Energy Metabolism
  • Humans
  • Lipid Metabolism
  • Non-alcoholic Fatty Liver Disease*

Substances

  • Antibodies
  • Basic-Leucine Zipper Transcription Factors
  • BATF protein, human

Associated data

  • GEO/GSE130970

Grants and funding

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.