Comparative Analysis of Anticancer and Antibacterial Activities among Seven Trametes Species

Ha Thi Kim Nguyen; Jiwon Lee; Yejin Park; Hyon Jin Park; Soon Kil Ahn; Jae Kwang Kim; Dong-Ku Kang; Minkyeong Kim; Chorong Ahn; Changmu Kim; Jaehyuk Choi

doi:10.1080/12298093.2023.2247218

Comparative Analysis of Anticancer and Antibacterial Activities among Seven Trametes Species

Mycobiology. 2023 Aug 29;51(4):256-263. doi: 10.1080/12298093.2023.2247218. eCollection 2023.

Authors

Affiliations

¹ Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, Korea.
² Department of Chemistry, College of Natural Sciences, Incheon National University, Incheon, Korea.
³ Species Diversity Research Division, National Institute of Biological Resources, Incheon, Korea.

Abstract

Species in the genus Trametes (Basidiomycota, Polyporales) have been used in natural medicine for a long time. Many studies reported that mycelia or fruiting bodies of Trametes spp. exhibited effects of antioxidant, anti-inflammatory, anticancer, and antimicrobial activities. However, comparative analysis in this genus is scarce due to limitation of morphological identification and the sample number. In this study, the 19 strains of seven Trametes species were chosen to generate a five-gene-based phylogeny with the 31 global references. In addition, 39 culture extracts were prepared for 13 strains to test for anticancer and antibacterial activities. Strong anticancer activities were found in several extracts from T. hirsuta and T. suaveolens. Anticancer activities of T. suaveolens, T. cf. junipericola and T. trogii were first described here. The antibacterial ability of T. versicolor and T. hirsuta extracts has been confirmed. The antibacterial activities of T. suaveolens have been reported at the first time in this study. These results suggest an efficient application of the genus Trametes as the drug resources especially for anticancer agents.

Keywords: Trametes; antibacterial; anticancer; antimicrobial; antitumor.

Grants and funding

This work was supported by a grant from the National Institute of Biological Resources (NIBR), funded by the Ministry of Environment (MOE) of the Korea (NIBR202102107) and the Incheon National University Institute of Convergence Science & Technology Research Grant.