Relationship between bone marrow adipose tissue and kidney function in postmenopausal women

Sammy Badr; Anne Cotten; Romuald Mentaverri; Daniela Lombardo; Julien Labreuche; Claire Martin; Lucie Hénaut; Bernard Cortet; Julien Paccou

doi:10.1016/j.bonr.2023.101713

Relationship between bone marrow adipose tissue and kidney function in postmenopausal women

Bone Rep. 2023 Sep 8:19:101713. doi: 10.1016/j.bonr.2023.101713. eCollection 2023 Dec.

Authors

Sammy Badr¹, Anne Cotten¹, Romuald Mentaverri², Daniela Lombardo³, Julien Labreuche⁴, Claire Martin⁴, Lucie Hénaut², Bernard Cortet³, Julien Paccou³

Affiliations

¹ Univ. Lille, CHU Lille, MABlab ULR 4490, Department of Radiology and Musculoskeletal Imaging, F-59000 Lille, France.
² UR UPJV 7517, Pathophysiological Mechanisms and Consequences of Cardiovascular Calcifications (MP3CV), Picardie Jules Verne University, 80025 Amiens, France.
³ Univ. Lille, CHU Lille, MABlab ULR 4490, Department of Rheumatology, F-59000 Lille, France.
⁴ CHU Lille, Department of Biostatistics, F-59000 Lille, France.

Abstract

Introduction: Bone marrow adipose tissue (BMAT) is associated with aging, osteoporosis, and chronic kidney disease (CKD). To date, the association between BMAT and kidney function in postmenopausal women has not been thoroughly investigated. The main purpose of this study was to determine whether a relationship exists between proton density fat fraction (PDFF) and kidney function in postmenopausal women.

Methods: We investigated the cross-sectional association between estimated glomerular filtration rate (eGFR) - calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation - and PDFF - measured at the lumbar spine and proximal femur using Water Fat Imaging (WFI) MRI - in 199 postmenopausal women from the ADIMOS cohort study. We also performed DXA scans and laboratory measurements of sclerostin and c-terminal Fibroblast Growth Factor 23 (cFGF23).

Results: Participants' mean age was 67.5 (standard deviation, SD 10.0) years. Their median eGFR was 85.0 (interquartile range, IQR 72.2-95.0) ml/min/1.73 cm², and their mean lumbar spine PDFF was 57.9 % (SD 9.6). When classified by eGFR-based CKD stages, 41.7 % of the cohort had an eGFR ≥ 90 (n = 83), 47.2 % had an eGFR of 60-89.9 (n = 94), and 11.1 % had an eGFR of 30-59.9 (n = 22). Participants with eGFR ≥ 90 had a lower lumbar spine PDFF than those with eGFR 60-89.9 (mean 55.8 % (9.8) vs. 58.9 % (9.0), p = 0.031) and those with eGFR 30-59.9 (55.8 % (9.8) vs. 60.8 % (9.8), p = 0.043). However, the differences did not remain significant after adjusting for predetermined confounders, including age, diabetes, Charlson comorbidity index, recent history of fragility fracture, appendicular lean mass, and lumbar spine BMD. The inclusion of sclerostin and/or cFGF23 as suspected mediators did not alter the findings. When proximal hip imaging-based PDFF was considered, no significant differences were found between the eGFR categories in the unadjusted and adjusted analyses.

Conclusion: No evidence of an association between kidney function and bone marrow adiposity was found either in the lumbar spine or proximal femur in a cohort of postmenopausal women.

Keywords: Bone marrow adipose tissue; Bone mineral density; Chronic kidney disease; Estimated glomerular filtration rate; Osteoporosis.