An updated overview of some factors that influence the biological effects of nanoparticles

Yang Xuan; Wenliang Zhang; Xinjiang Zhu; Shubiao Zhang

doi:10.3389/fbioe.2023.1254861

An updated overview of some factors that influence the biological effects of nanoparticles

Front Bioeng Biotechnol. 2023 Aug 30:11:1254861. doi: 10.3389/fbioe.2023.1254861. eCollection 2023.

Authors

Yang Xuan^#¹, Wenliang Zhang^#¹, Xinjiang Zhu^#², Shubiao Zhang¹

Affiliations

¹ Key Laboratory of Biological Resources and Utilization of Ministry of Education, Dalian Minzu University, Dalian, Liaoning, China.
² Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology, Dalian, Liaoning, China.

^# Contributed equally.

Abstract

Nanoparticles (NPs) can be extremely effective in the early diagnosis and treatment of cancer due to their properties. The nanotechnology industry is developing rapidly. The number of multifunctional NPs has increased in the market and hundreds of NPs are in various stages of preclinical and clinical development. Thus, the mechanism underlying the effects of NPs on biological systems has received much attention. After NPs enter the body, they interact with plasma proteins, tumour cell receptors, and small biological molecules. This interaction is closely related to the size, shape, chemical composition and surface modification properties of NPs. In this review, the effects of the size, shape, chemical composition and surface modification of NPs on the biological effects of NPs were summarised, including the mechanism through which NPs enter cells, the resulting oxidative stress response, and the interaction with proteins. This review of the biological effects of NPs can not only provide theoretical support for the preparation of safer and more efficient NPs but also lay the foundation for their clinical application.

Keywords: biological effects; interaction; nanoparticles; oxidative stress; protein corona.

Publication types

Review

Grants and funding

This work was financially supported by the National Natural Science Foundation of China (82001894/21776044), Applied Basic Research Program of Liaoning Province (2023JH2/101600018), Central Government for Scientific and Technological Development Guided Foundation of Dalian, Dalian Minzu University Service National Strategy Project (2020fwgj012), Innovation Research Project of Dalian Minzu University for Master Students.