Decoding the IBD paradox: A triadic interplay between REG3, enterococci, and NOD2

Xiaolong He; Hongwei Zhou

doi:10.1016/j.chom.2023.08.008

Decoding the IBD paradox: A triadic interplay between REG3, enterococci, and NOD2

Cell Host Microbe. 2023 Sep 13;31(9):1425-1427. doi: 10.1016/j.chom.2023.08.008.

Authors

Xiaolong He¹, Hongwei Zhou²

Affiliations

¹ Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510655, China.
² Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510655, China; State Key Laboratory of Organ Failure Research, Southern Medical University, Guangzhou, Guangdong, 510655, China. Electronic address: biodegradation@gmail.com.

PMID: 37708849
DOI: 10.1016/j.chom.2023.08.008

Abstract

In this issue of Cell Host & Microbe, Jang et al. decode an intriguing paradox: excessive antimicrobial peptide-regenerating family member 3 (REG3) expression in inflammatory bowel disease (IBD) patients depletes protective enterococci. This depletion impairs the NOD2 anti-inflammatory pathway and perpetuates inflammation, thus providing insight into IBD pathogenesis.

MeSH terms

Enterococcus / genetics
Humans
Inflammation
Inflammatory Bowel Diseases*
Nod2 Signaling Adaptor Protein / genetics

Substances

NOD2 protein, human
Nod2 Signaling Adaptor Protein
REG3A protein, human