MAMPs: A devil tamed becomes an angel

Huayuan Tang; Lin Wu

doi:10.1016/j.chom.2023.08.009

MAMPs: A devil tamed becomes an angel

Cell Host Microbe. 2023 Sep 13;31(9):1422-1425. doi: 10.1016/j.chom.2023.08.009.

Authors

Huayuan Tang¹, Lin Wu²

Affiliations

¹ Institute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, Guangdong Province, P.R. China.
² Institute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, Guangdong Province, P.R. China. Electronic address: lin.wu@szbl.ac.cn.

PMID: 37708848
DOI: 10.1016/j.chom.2023.08.009

Abstract

Symbiotic microorganisms modulate systemic immunity with unclear mechanisms. In this issue of Cell Host & Microbe, Clarke and colleagues uncover a coherent mechanism where the systemic spread of Firmicutes cell wall glycoconjugates enhances global immune fitness while simultaneously being delicately controlled to prevent systemic inflammation.

MeSH terms

Cell Wall*
Firmicutes*
Humans
Inflammation