A neuron-specific interaction between Alzheimer's disease risk factors SORL1, APOE, and CLU

Pranav Preman; Amaia M Arranz

doi:10.1016/j.celrep.2023.113129

A neuron-specific interaction between Alzheimer's disease risk factors SORL1, APOE, and CLU

Cell Rep. 2023 Sep 26;42(9):113129. doi: 10.1016/j.celrep.2023.113129. Epub 2023 Sep 13.

Authors

Pranav Preman¹, Amaia M Arranz²

Affiliations

¹ VIB Center for Brain & Disease Research, Leuven, Belgium; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven (University of Leuven), Leuven, Belgium.
² Achucarro Basque Center for Neuroscience, Leioa, Spain; Ikerbasque Basque Foundation for Science, Bilbao, Spain. Electronic address: amaia.arranz@achucarro.org.

PMID: 37708025
DOI: 10.1016/j.celrep.2023.113129

Abstract

Lee et al.¹ report that loss of the Alzheimer's disease risk factor SORL1 results in neuron-specific reduction in APOE and CLU, altered lipid homeostasis, and increased Aβ levels and phosphorylated Tau, both rescued by stabilizing retromer or enhancing autophagy.

Keywords: CP: Neuroscience.