Ambient-Temperature, Metal-Free, CDI-Mediated Ex-Situ Conversion of Acids to Amides: A Useful Late-Stage Strategy

Manisha A Patel; Anant R Kapdi

doi:10.1002/asia.202300672

Ambient-Temperature, Metal-Free, CDI-Mediated Ex-Situ Conversion of Acids to Amides: A Useful Late-Stage Strategy

Chem Asian J. 2023 Nov 16;18(22):e202300672. doi: 10.1002/asia.202300672. Epub 2023 Oct 18.

Authors

Manisha A Patel¹, Anant R Kapdi¹

Affiliation

¹ Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh Road, Matunga, Mumbai, 400019, India.

PMID: 37707494
DOI: 10.1002/asia.202300672

Abstract

An efficient ex-situ method for the amidation of carboxylic acids mediated by CDI has been disclosed herewith. This metal-free strategy is performed at ambient temperature and can be applied effectively for late-stage modification of amino acids and APIs.

Keywords: CDI; Dialkylamidation; Metal-free; N,N-dimethylformamide (DMF); carboxylic acid.