Recent progress in the development of ursolic acid derivatives as anti-diabetes and anti-cardiovascular agents

Yili Dai; Linjun Sun; Yan Tan; Wenyu Xu; Shu Liu; Jing Zhou; Yalin Hu; Jieying Lin; Xu Yao; Pengbing Mi; Xing Zheng

doi:10.1111/cbdd.14347

Recent progress in the development of ursolic acid derivatives as anti-diabetes and anti-cardiovascular agents

Chem Biol Drug Des. 2023 Dec;102(6):1643-1657. doi: 10.1111/cbdd.14347. Epub 2023 Sep 13.

Authors

Yili Dai¹, Linjun Sun², Yan Tan¹, Wenyu Xu¹, Shu Liu¹, Jing Zhou¹, Yalin Hu¹, Jieying Lin¹, Xu Yao¹, Pengbing Mi¹, Xing Zheng^{1

2}

Affiliations

¹ Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China, Hengyang, China.
² Department of Pharmacy, Hunan Vocational College of Science and Technology, Changsha, China.

PMID: 37705131
DOI: 10.1111/cbdd.14347

Abstract

Ursolic acid (UA) is a pentacyclic triterpenoid, which exhibits many biological activities, particularly in anti-cardiovascular and anti-diabetes. The further application of UA is greatly limited due to its low bioavailability and poor water solubility. Up to date, various UA derivatives have been designed to overcome these shortcomings. In this paper, the authors reviewed the development of UA derivatives as the anti-diabetes anti-cardiovascular reagents.

Keywords: anti-cardiovascular; anti-diabetes; ursolic acid derivatives.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Solubility
Triterpenes* / pharmacology
Triterpenes* / therapeutic use
Ursolic Acid

Substances

Triterpenes