Genomic Sequencing Surveillance to Identify Respiratory Syncytial Virus Mutations, Arizona, USA

LaRinda A Holland; Steven C Holland; Matthew F Smith; Victoria R Leonard; Vel Murugan; Lora Nordstrom; Mary Mulrow; Raquel Salgado; Michael White; Efrem S Lim

doi:10.3201/eid2911.230836

Genomic Sequencing Surveillance to Identify Respiratory Syncytial Virus Mutations, Arizona, USA

Emerg Infect Dis. 2023 Nov;29(11):2380-2382. doi: 10.3201/eid2911.230836. Epub 2023 Sep 13.

Authors

LaRinda A Holland, Steven C Holland, Matthew F Smith, Victoria R Leonard, Vel Murugan, Lora Nordstrom, Mary Mulrow, Raquel Salgado, Michael White, Efrem S Lim

Abstract

We conducted surveillance of respiratory syncytial virus (RSV) genomic sequences for 100 RSV-A and 27 RSV-B specimens collected during November 2022-April 2023 in Arizona, USA. We identified mutations within prefusion F-protein antigenic sites in both subtypes. Continued genomic surveillance will be critical to ensure RSV vaccine effectiveness.

Keywords: Arizona; RSV; United States; antigenic sites; genomic surveillance; respiratory infections; respiratory syncytial virus; viruses.

Publication types

Letter
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
Arizona / epidemiology
Humans
Mutation
Respiratory Syncytial Virus Infections* / epidemiology
Respiratory Syncytial Virus, Human* / genetics
Viral Fusion Proteins / genetics

Substances

Viral Fusion Proteins
Antibodies, Neutralizing
Antibodies, Viral