Preparation of lithium-containing magnesium phosphate-based composite ceramics having high compressive strength, osteostimulation and proangiogenic effects

Biomed Mater. 2023 Sep 21;18(6). doi: 10.1088/1748-605X/acf985.

Abstract

Fairly high concentrations of magnesium and lithium are conducive to improving the osteogenic and angiogenic capacities. In the current study, lithium-containing magnesium phosphate-based ceramics (AMP/LMPGs) were prepared from amorphous magnesium phosphate (AMP) at a low sintering temperature (650 °C), and the lithium/magnesium-containing phosphate glasses (LMPGs) were utilized as sintering additives. During the sintering procedure of AMP/LMPGs, the AMP reacted with LMPGs, producing new compounds. The AMP/LMPGs displayed nano-size grains and plentiful micropores. The addition of LMPGs noticeably increased the porosity as well as compressive strength of the AMP/LMPGs ceramics. The AMP/LMPGs sustainedly released Mg, P and Li ions, forming Mg-rich ionic microenvironment, which ameliorated cellular proliferation, osteogenic differentiation and proangiogenic capacities. The AMP/LMPGs ceramics with considerably high compressive strength, osteostimulation and proangiogenic effects were expected to efficiently regenerate the bone defects.

Keywords: bone repair; cellular behaviors; compressive strength; magnesium phosphate; phosphate-based glasses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ceramics
  • Compressive Strength
  • Lithium*
  • Magnesium*
  • Osteogenesis

Substances

  • magnesium phosphate
  • Lithium
  • Magnesium