Plaque attack by microglial PLCγ2

Ashley L Comer; Timothy R Hammond

doi:10.1016/j.immuni.2023.08.012

Plaque attack by microglial PLCγ2

Immunity. 2023 Sep 12;56(9):1985-1987. doi: 10.1016/j.immuni.2023.08.012.

Authors

Ashley L Comer¹, Timothy R Hammond²

Affiliations

¹ Sanofi, Rare and Neurologic Diseases, Cambridge, MA, USA.
² Sanofi, Rare and Neurologic Diseases, Cambridge, MA, USA. Electronic address: timothy.hammond@sanofi.com.

PMID: 37703828
DOI: 10.1016/j.immuni.2023.08.012

Abstract

PLCγ2 is genetically linked to Alzheimer's disease (AD), but it is unclear how PLCγ2 contributes to pathology. Tsai et al. demonstrate that AD-associated PLCG2 variants bidirectionally orchestrate microglial responses to plaques and impact neural function in an AD mouse model. This positions PLCγ2 as a key microglial signaling node and shows that targeting PLCγ2 could have therapeutic benefits in AD.

Publication types

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MeSH terms

Animals
Disease Models, Animal
Mice
Microglia*
Phospholipase C gamma / genetics
Plaque, Amyloid*

Substances

Phospholipase C gamma