A novel multifunctional fluorescent capillary-based sensor for simultaneous monitoring of pH, O2 and CO2

Xiaohui Wang; Yuanxiangyi Feng; Zhe Li; Jinhua Liu; Dandan Sun; Wei Yang; Xiaowei Xing; Wenjun Liu; Hongxin Zhang

doi:10.1016/j.saa.2023.123349

A novel multifunctional fluorescent capillary-based sensor for simultaneous monitoring of pH, O₂ and CO₂

Spectrochim Acta A Mol Biomol Spectrosc. 2024 Jan 5:304:123349. doi: 10.1016/j.saa.2023.123349. Epub 2023 Sep 7.

Authors

Xiaohui Wang¹, Yuanxiangyi Feng², Zhe Li², Jinhua Liu³, Dandan Sun², Wei Yang², Xiaowei Xing⁴, Wenjun Liu⁴, Hongxin Zhang²

Affiliations

¹ Beijing Key laboratory of Work Safety Intelligent Monitoring, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China. Electronic address: wangxiaohui@bupt.edu.cn.
² Beijing Key laboratory of Work Safety Intelligent Monitoring, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China.
³ Department of Pulmonary and Critical Care Medicine, The Third Hospital of Changsha, Changsha 410015, China.
⁴ School of Science, Beijing University of Posts and Telecommunications, Beijing 100876, China.

PMID: 37703794
DOI: 10.1016/j.saa.2023.123349

Abstract

A fluorescent capillary sensor for detecting the bioanalytically and biologically relevant analytes pH, O₂, and CO₂ has been designed. The sensor is based on single capillary tube with 2 mm inner diameter, which is simultaneous doped with emissive O₂-sensitive indicator Ru(dpp)₃(PF6)₂ (RuDP), pH-sensitive and CO₂-sensitive indicator 8-hydroxypyrene-1, 3,6-trisulfonic acid trisodium salt (HPTS). The multifunctional sensor can be excited at the same wavelength and realize multi-parameter optical monitoring at the different sensing position. Studies in phosphate-buffered solutions display the excellent feasibility of the capillary sensor for fluorescence detection of pH, O₂, and CO₂. Overall, the multifunctional capillary sensor exhibits great potential in real-time blood gas analysis, and clinical application of multi-parameter biological detection.

Keywords: CO(2) measurement; Capillary; Fluorescence; O(2) sensing; Optical sensor; pH detection.