Development of DACN-NHS-ester and DACN-maleimide, and their application for the synthesis of artificial hybrid biomolecules

Yuuya Kawasaki; Tomoya Hayashibara; Yuki Seto; Yutaro Taniguchi; Kazunobu Igawa; Katsuhiko Tomooka

doi:10.1039/d3cc03023g

Development of DACN-NHS-ester and DACN-maleimide, and their application for the synthesis of artificial hybrid biomolecules

Chem Commun (Camb). 2023 Sep 28;59(78):11724-11727. doi: 10.1039/d3cc03023g.

Authors

Yuuya Kawasaki¹, Tomoya Hayashibara², Yuki Seto², Yutaro Taniguchi², Kazunobu Igawa^{1

2}, Katsuhiko Tomooka^{1

2}

Affiliations

¹ Institute for Materials Chemistry and Engineering, and IRCCS, Kyushu University, Kasuga, Fukuoka 816-8580, Japan. ktomooka@cm.kyushu-u.ac.jp.
² Department of Molecular and Material Sciences, Kyushu University, Kasuga, Fukuoka 816-8580, Japan.

PMID: 37702377
DOI: 10.1039/d3cc03023g

Abstract

DACN-NHS-ester and DACN-maleimide were developed as molecular connectors and applied for the synthesis of artificial hybrid biomolecules in two steps, including, step 1: connection to a corresponding molecule via the NHS ester or maleimide unit, followed by step 2: connection to a corresponding azido-containing molecule via DACN unit by copper-free-alkyne-azide-cycloaddition.

MeSH terms

Alkynes
Azides*
Catalysis
Cycloaddition Reaction
Maleimides
State Medicine*

Substances

Azides
Maleimides
Alkynes