BBOX1-AS1: A novel oncogenic long non-coding RNA in human cancers

Renfang Zhang; Xiaohui Gao; Xinyu Gu

doi:10.1016/j.prp.2023.154810

BBOX1-AS1: A novel oncogenic long non-coding RNA in human cancers

Pathol Res Pract. 2023 Oct:250:154810. doi: 10.1016/j.prp.2023.154810. Epub 2023 Sep 9.

Authors

Renfang Zhang¹, Xiaohui Gao², Xinyu Gu³

Affiliations

¹ Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.
² Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, Henan, China.
³ Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, Henan, China. Electronic address: China.hkdguxy@163.com.

PMID: 37696243
DOI: 10.1016/j.prp.2023.154810

Abstract

Long non-coding RNAs (lncRNAs) are transcripts that contain more than 200 nucleotides. Despite the fact that they cannot encode proteins, many studies have identified roles they play in human cancers through diverse mechanisms. BBOX1-AS1, an oncogenic lncRNA, has recently been demonstrated to participate in tumorigenesis and progression of numerous cancers. Experimental evidence has determined that it participates in diverse biological process, including cell proliferation, invasion, migration, and apoptosis. The dysregulation of BBOX1-AS1 exerts its oncogenicity by acting as a competitive endogenous RNA (ceRNA) or by directly impacting downstream molecules and signaling pathways. Here we summarize the current understanding of the biological functions and clinical significance of BBOX1-AS1 for human cancers.

Keywords: BBOX1-AS1; Cancer; LncRNA; Malignant tumor.

Publication types

Review