Recent progress of Holter-based late potential for predicting serious cardiac events and its implications and future challenges

Abstract

Late potential (LP) has recently been measured using Holter electrocardiogram (H-LP), and accumulating evidence suggests that it is a useful approach for detecting lethal arrhythmias and sudden cardiac death, especially in cases of ischemic heart disease. In this review, our primary objective was to advance the understanding and utilization of H-LP by elucidating the existing unresolved aspects, thereby serving as a guide for future research in this domain. Particularly, the combination of H-LP with non-sustained ventricular tachycardia, rather than LP alone, may improve the accuracy of the test. H-LP parameters show diurnal variations in both patients with cardiac disease and healthy individuals. Although H-LP shows promise as the future mainstream LP test, there are several problems; specifically, handling noise levels when H-LP is performed in unrestricted daily activities. Additionally, a reference value that considers diurnal variations has not yet been established. These challenges need to be addressed to improve the viability and clinical use of H-LP. By incorporating H-LP into routine assessments, healthcare practitioners can gain valuable insights into the cardiovascular health of their patients, facilitating timely interventions and better disease management.

Keywords: Brugada syndrom; Holter electrocardiogram; Ischemic heart disease; Late potential; Signal-averaged electrocardiogram.