Quantitative MRI protocol and decision model for a 'one stop shop' early-stage Parkinsonism diagnosis: Study design

Samy Abo Seada; Anke W van der Eerden; Agnita J W Boon; Juan A Hernandez-Tamames

doi:10.1016/j.nicl.2023.103506

Quantitative MRI protocol and decision model for a 'one stop shop' early-stage Parkinsonism diagnosis: Study design

Neuroimage Clin. 2023:39:103506. doi: 10.1016/j.nicl.2023.103506. Epub 2023 Sep 9.

Authors

Samy Abo Seada¹, Anke W van der Eerden¹, Agnita J W Boon², Juan A Hernandez-Tamames³

Affiliations

¹ Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
² Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.
³ Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands; Department of Imaging Physics, TU Delft, The Netherlands. Electronic address: j.hernandeztamames@erasmusmc.nl.

Abstract

Differentiating among early-stage parkinsonisms is a challenge in clinical practice. Quantitative MRI can aid the diagnostic process, but studies with singular MRI techniques have had limited success thus far. Our objective is to develop a multi-modal MRI method for this purpose. In this review we describe existing methods and present a dedicated quantitative MRI protocol, a decision model and a study design to validate our approach ahead of a pilot study. We present example imaging data from patients and a healthy control, which resemble related literature.

Keywords: Atypical parkinsonisms; DTI; MSA; Multi-modal; PSP; Parkinson; QSM; Quantitative MRI.

Publication types

Review

MeSH terms

Humans
Magnetic Resonance Imaging
Parkinsonian Disorders* / diagnostic imaging
Pilot Projects
Research Design*