SAPHO syndrome complicated by multiple venous thrombosis of left lower limb: A case report and literature review

Int J Rheum Dis. 2024 Jan;27(1):e14880. doi: 10.1111/1756-185X.14880. Epub 2023 Sep 11.

Abstract

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an uncommon clinical syndrome with the signs of skin problems and osteoarthropathy as its main features. The pathogenesis of SAPHO syndrome has not been fully elucidated, and multiple complications may be present, including thrombosis. A 39-year-old male patient was diagnosed with SAPHO syndrome, complicated by multiple venous thrombosis of the left lower limb. We conducted a brief review of the current available literature on thrombosis in patients with SAPHO syndrome and speculated that the presence of lower extremity thrombosis in this patient with SAPHO syndrome may be related to physiological structure or antiphospholipid syndrome. Whether positive lupus anticoagulant has an effect on thrombosis in patients with SAPHO syndrome remains to be investigated.

Keywords: SAPHO syndrome; antiphospholipid syndrome; comorbidity; lupus anticoagulants; thrombus.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Acne Vulgaris* / complications
  • Acquired Hyperostosis Syndrome* / complications
  • Acquired Hyperostosis Syndrome* / diagnosis
  • Acquired Hyperostosis Syndrome* / drug therapy
  • Adult
  • Antiphospholipid Syndrome* / complications
  • Antiphospholipid Syndrome* / diagnosis
  • Antiphospholipid Syndrome* / drug therapy
  • Humans
  • Male
  • Osteitis*
  • Synovitis* / complications
  • Venous Thrombosis* / diagnostic imaging
  • Venous Thrombosis* / drug therapy
  • Venous Thrombosis* / etiology