Recent Advances in the Management of Adverse Events Associated with Lorlatinib

Dehua Liao; Jiwen Zhang; Ting Yan; Shanshan Chen; Wei Li; Dangang Shangguan; Zhihua She

doi:10.2147/OTT.S426989

Recent Advances in the Management of Adverse Events Associated with Lorlatinib

Onco Targets Ther. 2023 Sep 5:16:731-738. doi: 10.2147/OTT.S426989. eCollection 2023.

Authors

Dehua Liao¹, Jiwen Zhang^{1

2}, Ting Yan¹, Shanshan Chen¹, Wei Li¹, Dangang Shangguan^#¹, Zhihua She^#³

Affiliations

¹ Department of Pharmacy, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People's Republic of China.
² School of Pharmacy, University of South China, Hengyang, People's Republic of China.
³ Department of Medical Administration, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, People's Republic of China.

^# Contributed equally.

Abstract

As a novel third-generation ALK tyrosine kinase inhibitor (TKI), lorlatinib has shown excellent systemic and intracranial activity in non-small cell lung cancer (NSCLC) patients who carry sensitizing ALK-activating mutations and progress on first- and second-generation TKIs. In comparison with other ALK-TKIs, lorlatinib has a unique safety profile for hyperlipidemia and central nervous system adverse events. Lorlatinib-induced adverse events are well tolerated, permanent discontinuations are rarely reported, and dose modifications and/or standard medical therapy are useful for the management of adverse events. Our present study reviews the safety profile of lorlatinib as well as the relevant management strategies. Our present study aims to provide a practical guide for the scientific management and application of lorlatinib.

Keywords: ALK; NSCLC; adverse event; lorlatinib; therapy management.

Publication types

Review

Grants and funding

This study was supported by Hunan Pharmaceutical Association Foundation (No: 2020YXH001), Hunan Provincial Natural Science Foundation of China (No: 2021JJ70025), and Climbing Plan of Hunan Cancer Hospital (No: 2021NSFC-A003).