The effect of different sources of mesenchymal stem cells on microglia states

Qiang Xin; Wenhao Zhu; Chuan He; Tianyi Liu; Haifeng Wang

doi:10.3389/fnagi.2023.1237532

The effect of different sources of mesenchymal stem cells on microglia states

Front Aging Neurosci. 2023 Aug 24:15:1237532. doi: 10.3389/fnagi.2023.1237532. eCollection 2023.

Authors

Qiang Xin¹, Wenhao Zhu¹, Chuan He¹, Tianyi Liu¹, Haifeng Wang¹

Affiliation

¹ Department of Neurotrauma Surgery, The First Hospital of Jilin University, Changchun, China.

Abstract

Microglial reaction plays a key role in the prognosis of traumatic CNS injuries (TBI and SCI). A growing number of studies have shown that mesenchymal stem cells (MSCs) play an important role in regulating microglial states. This review summarizes the effects and mechanisms of different sources of MSCs on microglial states in the last 5 years. In general, bone marrow-derived mesenchymal stem cells are the most accessible and widely used, and can produce immunosuppressive effects on a variety of brain injuries including TBI through tissue engineering in situ implantation; MSCs mainly regulate inflammatory pathways and promote the states of microglia in the anti-inflammatory direction, which also secrete certain cytokines or extracellular vesicles to affect apoptotic pathways, such as the extracellular vesicles miR-21-5p, acting as a neuronal protector.

Keywords: different sources; effect; mesenchymal stem cells; microglia; states.

Publication types

Review

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (No. 81871555), the Department of Finance of Jilin Province (JLSCZD2019-006, 2018SCZWSZX-006, and JLSWSRCZX2021-028), and the Jilin Province Development and Reform Commission (ZKJCFGW2023038).