Single-cell RNA sequencing in juvenile idiopathic arthritis

Xiwen Luo; Xuemei Tang

doi:10.1016/j.gendis.2023.04.014

Single-cell RNA sequencing in juvenile idiopathic arthritis

Genes Dis. 2023 May 24;11(2):633-644. doi: 10.1016/j.gendis.2023.04.014. eCollection 2024 Mar.

Authors

Xiwen Luo¹, Xuemei Tang^{1

2}

Affiliations

¹ Department of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
² Chongqing Key Laboratory of Child Infection and Immunity, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

Abstract

Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children, with onset before age 16 and lasting for more than 6 weeks. JIA is a highly heterogeneous condition with various consequences for health and quality of life. For some JIA patients, early detection and intervention remain challenging. As a result, further investigation of the complex and unknown mechanisms underlying JIA is required. Advances in technology now allow us to describe the biological heterogeneity and function of individual cell populations in JIA. Through this review, we hope to provide novel ideas and potential targets for the diagnosis and treatment of JIA by summarizing the current findings of single-cell RNA sequencing studies and understanding how the major cell subsets drive JIA pathogenesis.

Keywords: Juvenile idiopathic arthritis; Macrophage; Macrophage activation syndrome; Monocyte; Single-cell RNA sequencing; Synoviocyte; T cell.

Publication types

Review