Brain response in asthma: the role of "lung-brain" axis mediated by neuroimmune crosstalk

Front Immunol. 2023 Aug 24:14:1240248. doi: 10.3389/fimmu.2023.1240248. eCollection 2023.

Abstract

In addition to typical respiratory symptoms, patients with asthma are frequently accompanied by cognitive decline, mood disorders (anxiety and depression), sleep disorders, olfactory disorders, and other brain response manifestations, all of which worsen asthma symptoms, form a vicious cycle, and exacerbate the burden on families and society. Therefore, studying the mechanism of neurological symptoms in patients with asthma is necessary to identify the appropriate preventative and therapeutic measures. In order to provide a comprehensive reference for related research, we compiled the pertinent literature, systematically summarized the latest research progress of asthma and its brain response, and attempted to reveal the possible "lung-brain" crosstalk mechanism and treatment methods at the onset of asthma, which will promote more related research to provide asthmatic patients with neurological symptoms new hope.

Keywords: asthma; brain response; inflammatory response; lung-brain axis; neuro-immune.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anxiety
  • Anxiety Disorders
  • Asthma*
  • Brain
  • Humans
  • Lung

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (82071021, 82271146); the Key Research and Development Program of Shandong Province (Major Science and Technology Innovation Project) (2020CXGC011302, 2022CXGC020506); the Shandong Provincial Postdoctoral Foundation Project(Innovation Project)(SDCX-ZG-202203077); and the outstanding young talents project in health of Qilu.