Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome

EMBO J. 2023 Oct 16;42(20):e115307. doi: 10.15252/embj.2023115307. Epub 2023 Sep 11.

Abstract

Removal of polyploid cells is essential to preventing cancer and restricting tumor growth. A new study published in The EMBO Journal shows assembly of the NEMO-PIDDosome on extra centrioles. Activation of this protein complex leads to NF-κB activation that, in turn, induces NK cell-mediated cell clearance.

Publication types

  • Comment

MeSH terms

  • Gene Expression Regulation
  • Humans
  • I-kappa B Kinase / metabolism
  • Killer Cells, Natural
  • NF-kappa B* / metabolism
  • Polyploidy
  • Signal Transduction*

Substances

  • I-kappa B Kinase
  • NF-kappa B
  • PIDD1 protein, human
  • Pidd1 protein, mouse