Synthesis of rare-earth metal-organic frameworks to construct high-resolution sensing array for multiplex anions detection, cell imaging and blood phosphorus monitoring

Gongle Shen; Linling Zhong; Guizhu Liu; Liu Yang; Xin Wen; Guanxi Chen; Jiangqi Zhao; Changjun Hou; Xianfeng Wang

doi:10.1016/j.jcis.2023.09.010

Synthesis of rare-earth metal-organic frameworks to construct high-resolution sensing array for multiplex anions detection, cell imaging and blood phosphorus monitoring

J Colloid Interface Sci. 2023 Dec 15;652(Pt B):1925-1936. doi: 10.1016/j.jcis.2023.09.010. Epub 2023 Sep 8.

Authors

Gongle Shen¹, Linling Zhong¹, Guizhu Liu¹, Liu Yang¹, Xin Wen¹, Guanxi Chen¹, Jiangqi Zhao², Changjun Hou³, Xianfeng Wang⁴

Affiliations

¹ Wuxi School of Medicine, Jiangnan University, Wuxi 214122, PR China.
² College of Materials Science and Engineering, Sichuan University, Chengdu 610065, PR China.
³ Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, PR China.
⁴ Wuxi School of Medicine, Jiangnan University, Wuxi 214122, PR China; Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, PR China. Electronic address: wxfeng@jiangnan.edu.cn.

PMID: 37690300
DOI: 10.1016/j.jcis.2023.09.010

Abstract

Accurate detection and differentiation of multiple anions is still a difficult problem due to their wide variety, structural similarity, and mutual interference. Hence, four rare-earth metal-organic frameworks (RE-MOFs) including Dy-MOFs, Er-MOFs, Tb-MOFs and Y-MOFs are successfully prepared by using TCPP as the ligand and rare-earth ions as the metal center via coordination chelation. It is found that 7 anions can light up their fluorescence. Thus, a high-resolution sensing array based on RE-MOFs nanoprobes is employed to differentiate these anions from intricate analytes in real-time scenarios. The distinctive host-guest response promotes the RE-MOFs nanoprobes to selectively extract the target anions from the complex samples. By taking advantage of the cross-response between RE-MOFs nanoprobes and anions, it allows to create an array for detecting target analytes using pattern recognition. Additionally, RE-MOFs nanoprobes also facilitate the quantitative analysis of these anions (PO₄^3-, H₂PO₄^-, HPO₄^2-, F^-, S^2-, CO₃^2- and C₂O₄^2-). More importantly, the exceptional effectiveness of this method has been demonstrated through various successful applications, including quality monitoring of 8 toothpaste brands, intracellular phosphate imaging, and blood phosphorus detection in mice with vascular calcification. These findings provide robust evidence for the efficacy and reliability of the RE-MOFs nanoprobes array for anion recognition.

Keywords: Anions detection; Fluorescence detection; Pattern recognition; Rare-earth metal-organic frameworks; Sensing array.