Etiologies of Brain Arteriovenous Malformation Recurrence: A Focus on Pediatric Disease

David C Lauzier; Sarah N Chiang; Christopher J Moran

doi:10.1016/j.pediatrneurol.2023.08.022

Etiologies of Brain Arteriovenous Malformation Recurrence: A Focus on Pediatric Disease

Pediatr Neurol. 2023 Nov:148:94-100. doi: 10.1016/j.pediatrneurol.2023.08.022. Epub 2023 Aug 22.

Authors

David C Lauzier¹, Sarah N Chiang², Christopher J Moran³

Affiliations

¹ Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri. Electronic address: dlauzier@wustl.edu.
² Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri.
³ Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.

PMID: 37690270
DOI: 10.1016/j.pediatrneurol.2023.08.022

Abstract

Pediatric brain arteriovenous malformations are a major cause of morbidity and mortality, with the harmful effects of this disease compounded by the additional disability-years experienced by children with ruptured or other symptomatic arteriovenous malformations. In addition to the risks shared with their adult counterparts, pediatric patients frequently experience recurrence following radiographic cure, which presents an additional source of morbidity and mortality. Therefore, there is a need to synthesize potential mechanisms contributing to the elevated recurrence risk in the pediatric population and discuss how these translate to practical considerations for managing these patients.

Keywords: Brain AVM; Intracranial hemorrhage; Pediatric Hemorrhage; Recurrence; Subarachonid Hemorrhage.

Publication types

Review