Synthesis and Biological Activities of Luminescent 5,6-Membered Bis(Metallacyclic) Platinum(II) Complexes

Jing Jing; Miao Yu; Lei Pan; Yang Zhao; Guo Xu; Hua-Hong Zhang; Chen Li; Xiao-Peng Zhang

doi:10.3390/molecules28176369

Synthesis and Biological Activities of Luminescent 5,6-Membered Bis(Metallacyclic) Platinum(II) Complexes

Molecules. 2023 Aug 31;28(17):6369. doi: 10.3390/molecules28176369.

Authors

Jing Jing¹, Miao Yu¹, Lei Pan¹, Yang Zhao¹, Guo Xu¹, Hua-Hong Zhang¹, Chen Li¹, Xiao-Peng Zhang¹

Affiliation

¹ Key Laboratory of Water Pollution Treatment & Resource Reuse of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.

Abstract

Four couples of 5,6-membered bis(metallacyclic) Pt(II) complexes with acetylide and isocyanide auxiliary ligands have been prepared and characterized. The structures of (-)-2 and (-)-3 are confirmed by single-crystal X-ray diffraction, showing a distorted square-planar coordination environment around the Pt(II) nucleus. Both solutions and solid samples of all complexes are emissive at RT. Acetylide-coordinated Pt(II) complexes have a lower energy emission than those isocyanide-coordinated ones. The emission spectra of N^N'*C-coordinated Pt(II) derivatives show a lower energy emission maximum relative to N^C*N'-coordinated complexes with the same auxiliary ligand. Moreover, the difference between cyclometalated N^N'*C and N^C*N' ligands exerts a more remarkable effect on the emission than the auxiliary ligands acetylide and isocyanide. Cytotoxicity and cell imaging of luminescent 5,6-membered bis(metallacyclic) Pt(II) complexes have been evaluated.

Keywords: 5,6-membered bis(metallacycle); biological activities; crystal structures; emission; platinum(II) complexes.

Grants and funding

This research was funded by the Natural Science Foundation of Hainan Province (no. ZDYF2023SHFZ106, 220RC591), the National Natural Science Foundation of China (no. 21961009), and the Graduate Students Research Foundation of Hainan Normal University (no. Qhys2022-209).