Integrins and Actions of Androgen in Breast Cancer

Chung-Che Tsai; Yu-Chen S H Yang; Yi-Fong Chen; Lin-Yi Huang; Yung-Ning Yang; Sheng-Yang Lee; Wen-Long Wang; Hsin-Lun Lee; Jacqueline Whang-Peng; Hung-Yun Lin; Kuan Wang

doi:10.3390/cells12172126

Integrins and Actions of Androgen in Breast Cancer

Cells. 2023 Aug 22;12(17):2126. doi: 10.3390/cells12172126.

Authors

Chung-Che Tsai^{1

2}, Yu-Chen S H Yang³, Yi-Fong Chen¹, Lin-Yi Huang⁴, Yung-Ning Yang^{4

5}, Sheng-Yang Lee^{6

7}, Wen-Long Wang⁸, Hsin-Lun Lee^{9

10

11}, Jacqueline Whang-Peng¹², Hung-Yun Lin^{1

12

13

14

15}, Kuan Wang²

Affiliations

¹ Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
² Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
³ Joint Biobank, Office of Human Research, Taipei Medical University, Taipei 11031, Taiwan.
⁴ Department of Pediatrics, E-DA Hospital, I-Shou University, Kaohsiung 82445, Taiwan.
⁵ School of Medicine, I-Shou University, Kaohsiung 82445, Taiwan.
⁶ Dentistry, Wan-Fang Medical Center, Taipei Medical University, Taipei 11031, Taiwan.
⁷ School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
⁸ Department of Life Science, Fu Jen Catholic University, New Taipei City 242, Taiwan.
⁹ Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
¹⁰ Department of Radiation Oncology, Taipei Medical University Hospital, Taipei 110, Taiwan.
¹¹ The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan.
¹² Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
¹³ TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan.
¹⁴ Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan.
¹⁵ Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA.

Abstract

Androgen has been shown to regulate male physiological activities and cancer proliferation. It is used to antagonize estrogen-induced proliferative effects in breast cancer cells. However, evidence indicates that androgen can stimulate cancer cell growth in estrogen receptor (ER)-positive and ER-negative breast cancer cells via different types of receptors and different mechanisms. Androgen-induced cancer growth and metastasis link with different types of integrins. Integrin αvβ3 is predominantly expressed and activated in cancer cells and rapidly dividing endothelial cells. Programmed death-ligand 1 (PD-L1) also plays a vital role in cancer growth. The part of integrins in action with androgen in cancer cells is not fully mechanically understood. To clarify the interactions between androgen and integrin αvβ3, we carried out molecular modeling to explain the potential interactions of androgen with integrin αvβ3. The androgen-regulated mechanisms on PD-L1 and its effects were also addressed.

Keywords: PD-L; androgen; androgen receptor; breast cancer; integrin αvβ3.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Androgens* / pharmacology
B7-H1 Antigen*
Cell Transformation, Neoplastic
Endothelial Cells
Humans
Integrin alphaVbeta3
Male

Substances

Androgens
B7-H1 Antigen
Integrin alphaVbeta3

Grants and funding

This work was supported in part by intra-institutional grants from E-Da Medical Center, Taiwan (EDAHP112024 and EDPJ111068 to Y.-N.Y.), by a 33-research grant from E-Da Medical Center, Taiwan (EDAHS112025 to Y.-N.Y., and EDAHS112031 to L.-Y.H.), by the Chair Professor Research Fund to J.W.-P. and K. Wang, by the TMU Research Center of Cancer Translational Medicine from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan (DP2-107-20000), by a grant from the Ministry of Science and Technology, Taiwan (NSTC112-2811-B-038-005 to C.-C.T.; MOST109-2314-B-038-038 to Y.-C.S.H.Y.; MOST110-2314-B-038-147 and MOST111-2314-B-038-123 to H.-Y.L.), and by an integrated grant from the Ministry of Science and Technology, Taiwan (NSTC111-2314-B-038-014 to J.W.-P., NSTC111-2314-B-038-015 to H.-Y.L. and NSTC111-2314-B-038-016 to K. Wang).