Bioavailability of Li-enriched mushrooms and protection against oxidative stress in pigs: First study in vivo

Leandro de Souza Lopes; Marliane de Cássia Soares da Silva; Juliana Soares da Silva; José Maria Rodrigues da Luz; Alessandra de Oliveira Faustino; Gabriel Cipriano Rocha; Leandro Licursi de Oliveira; Maria Catarina Megumi Kasuya

doi:10.1007/s13205-023-03731-8

Bioavailability of Li-enriched mushrooms and protection against oxidative stress in pigs: First study in vivo

3 Biotech. 2023 Oct;13(10):334. doi: 10.1007/s13205-023-03731-8. Epub 2023 Sep 5.

Authors

Leandro de Souza Lopes¹, Marliane de Cássia Soares da Silva¹, Juliana Soares da Silva¹, José Maria Rodrigues da Luz¹, Alessandra de Oliveira Faustino², Gabriel Cipriano Rocha³, Leandro Licursi de Oliveira¹, Maria Catarina Megumi Kasuya¹

Affiliations

¹ Department of Agricultural Microbiology, Universidade Federal de Viçosa, Av. Peter Henry Rolfs, s/n, 36570-000, Viçosa, Minas Gerais Brazil.
² Department of Cell Biology, Universidade Federal de Viçosa, Av. Peter Henry Rolfs, s/n, 36570-000, Viçosa, Minas Gerais Brazil.
³ Department of Animal Science, Universidade Federal de Viçosa, Av. Peter Henry Rolfs, s/n, 36570-000, Viçosa, Minas Gerais Brazil.

PMID: 37681112
PMCID: PMC10480122 (available on 2024-10-01)
DOI: 10.1007/s13205-023-03731-8

Abstract

Mycelia and mushrooms are able to bioaccumulate minerals. Lithium is the active principle of drugs used in the treatment of psychiatric diseases. However, a dietary source of Li can reduce the side effects of these drugs. Thus, the objective of this study was to evaluate the bioavailability of Li-enriched mushroom of Pleurotus djamor in pigs and the effects of this element on oxidative stress in the animal tissues. Pigs 28-30 days-old were fed with diets containing or not Li for five days. Levels of serum cortisol were related to the Li dosage from diet. Li-enriched mushrooms were more bioavailable source of Li to the body than Li₂CO₃. These mushrooms also improved the effects of oxidative enzymes and showed less oxidative damage than Li₂CO₃. These results demonstrate the potential to use Li-enriched P. djamor as a source of Li that is more bioavailable and present protective effects against oxidative stress.

Keywords: Blood; Brain; Functional food; Liver; Oxidative stress.

© King Abdulaziz City for Science and Technology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.