Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer

Jinbowen Yan; Fangzhi Xu; Dan Zhou; Shuo Zhang; Bo Zhang; Qingwei Meng; Qiubo Lv

doi:10.3389/fonc.2023.1231460

Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer

Front Oncol. 2023 Aug 22:13:1231460. doi: 10.3389/fonc.2023.1231460. eCollection 2023.

Authors

Jinbowen Yan¹, Fangzhi Xu², Dan Zhou¹, Shuo Zhang¹, Bo Zhang¹, Qingwei Meng¹, Qiubo Lv¹

Affiliations

¹ Department of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
² The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital, National Center of Gerontology of National Health Commission, Beijing, China.

Abstract

Metabolic reprogramming is a phenomenon in which cancer cells alter their metabolic pathways to support their uncontrolled growth and survival. Platinum-based chemotherapy resistance is associated with changes in glucose metabolism, amino acid metabolism, fatty acid metabolism, and tricarboxylic acid cycle. These changes lead to the creation of metabolic intermediates that can provide precursors for the biosynthesis of cellular components and help maintain cellular energy homeostasis. This article reviews the research progress of the metabolic reprogramming mechanism of platinumbased chemotherapy resistance caused by three major nutrients in ovarian cancer.

Keywords: amino acid metabolism; glucose metabolism; lipid metabolism; metabolic reprogramming; ovarian cancer; platinum resistance.

Publication types

Review