Lipid and glucose metabolism in senescence

Bin Liu; Qingfei Meng; Xin Gao; Huihui Sun; Zhixiang Xu; Yishu Wang; Honglan Zhou

doi:10.3389/fnut.2023.1157352

Lipid and glucose metabolism in senescence

Front Nutr. 2023 Aug 23:10:1157352. doi: 10.3389/fnut.2023.1157352. eCollection 2023.

Authors

Bin Liu¹, Qingfei Meng², Xin Gao¹, Huihui Sun², Zhixiang Xu², Yishu Wang², Honglan Zhou¹

Affiliations

¹ Department of Urology II, The First Hospital of Jilin University, Changchun, Jilin, China.
² Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, Jilin, China.

Abstract

Senescence is an inevitable biological process. Disturbances in glucose and lipid metabolism are essential features of cellular senescence. Given the important roles of these types of metabolism, we review the evidence for how key metabolic enzymes influence senescence and how senescence-related secretory phenotypes, autophagy, apoptosis, insulin signaling pathways, and environmental factors modulate glucose and lipid homeostasis. We also discuss the metabolic alterations in abnormal senescence diseases and anti-cancer therapies that target senescence through metabolic interventions. Our work offers insights for developing pharmacological strategies to combat senescence and cancer.

Keywords: ACC; ACOX1; CPT1; PPP; TCA; glycolysis; lipid metabolism; senescence.

Publication types

Review