Latest advances in the regulatory genes of adipocyte thermogenesis

Front Endocrinol (Lausanne). 2023 Aug 23:14:1250487. doi: 10.3389/fendo.2023.1250487. eCollection 2023.

Abstract

An energy imbalance cause obesity: more energy intake or less energy expenditure, or both. Obesity could be the origin of many metabolic disorders, such as type 2 diabetes and cardiovascular disease. UCP1 (uncoupling protein1), which is highly and exclusively expressed in the thermogenic adipocytes, including beige and brown adipocytes, can dissipate proton motive force into heat without producing ATP to increase energy expenditure. It is an attractive strategy to combat obesity and its related metabolic disorders by increasing non-shivering adipocyte thermogenesis. Adipocyte thermogenesis has recently been reported to be regulated by several new genes. This work provided novel and potential targets to activate adipocyte thermogenesis and resist obesity, such as secreted proteins ADISSP and EMC10, enzyme SSU72, etc. In this review, we have summarized the latest research on adipocyte thermogenesis regulation to shed more light on this topic.

Keywords: PKA; UCP1; adipocyte thermogenesis; adrenergic signaling pathway; obesity.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipocytes, Brown
  • Diabetes Mellitus, Type 2*
  • Genes, Regulator
  • Humans
  • Membrane Proteins
  • Obesity / genetics
  • Phosphoprotein Phosphatases
  • Thermogenesis / genetics

Substances

  • SSU72 protein, human
  • Phosphoprotein Phosphatases
  • EMC10 protein, human
  • Membrane Proteins

Grants and funding

This study was supported in part by the National Natural Science Foundation of China (81970729), the Natural Science Foundation of Guangdong province (2022A1515010283), initial funding from Hubei University of Arts and Science (2059200), and Pearl River S&T Nova Program of Guangzhou (201806010166).