Linezolid toxic optic neuropathy: A case report and review of visual prognosis

Kevin J Toolan; Jacob Fondriest; Kaitlin Keenan; Thomas Mizen; Milena Stosic

doi:10.1016/j.ajoc.2023.101922

Linezolid toxic optic neuropathy: A case report and review of visual prognosis

Am J Ophthalmol Case Rep. 2023 Aug 26:32:101922. doi: 10.1016/j.ajoc.2023.101922. eCollection 2023 Dec.

Authors

Kevin J Toolan¹, Jacob Fondriest¹, Kaitlin Keenan², Thomas Mizen^{1

2}, Milena Stosic²

Affiliations

¹ Department of Ophthalmology, Rush University, Chicago, IL, USA.
² Department of Neurological Sciences Faculty and Staff, Rush University, Chicago, IL, USA.

Abstract

Purpose: To describe a case of linezolid toxic optic neuropathy in a 71-year-old female and review the relevant literature.

Observations: An adult female with progressive, symmetric vision loss was hypothesized to have linezolid toxic optic neuropathy. Following cessation of linezolid, the patient experienced improvement in visual function over two months.

Conclusions and importance: Patients diagnosed with linezolid toxic optic neuropathy can expect some return of visual function after cessation. The degree of return does not correlate to the cumulative dose of the drug. The goal of this study was to summarize and add to the current body of literature on the topic.

Keywords: Linezolid; Non-organic visual disorders; Ocular toxicity; Optic nerve; Toxic optic neuropathy.

Publication types

Case Reports