Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis

Sachin Sharma; Dounia Le Guillou; Jennifer Y Chen

doi:10.1038/s41575-023-00832-w

Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis

Nat Rev Gastroenterol Hepatol. 2023 Oct;20(10):662-678. doi: 10.1038/s41575-023-00832-w. Epub 2023 Sep 7.

Authors

Sachin Sharma^#^{1

2}, Dounia Le Guillou^#^{1

2}, Jennifer Y Chen^{3

4}

Affiliations

¹ Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
² The Liver Center, University of California, San Francisco, San Francisco, CA, USA.
³ Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Jennifer.Chen4@ucsf.edu.
⁴ The Liver Center, University of California, San Francisco, San Francisco, CA, USA. Jennifer.Chen4@ucsf.edu.

^# Contributed equally.

PMID: 37679454
DOI: 10.1038/s41575-023-00832-w

Abstract

The burden of chronic liver disease is rising substantially worldwide. Fibrosis, characterized by excessive deposition of extracellular matrix proteins, is the common pathway leading to cirrhosis, and limited treatment options are available. There is increasing evidence suggesting the role of cellular stress responses contributing to fibrogenesis. This Review provides an overview of studies that analyse the role of cellular stress in different cell types involved in fibrogenesis, including hepatocytes, hepatic stellate cells, liver sinusoidal endothelial cells and macrophages.

Publication types

Review

MeSH terms

Endothelial Cells
Hepatic Stellate Cells
Hepatocytes
Humans
Liver Cirrhosis / etiology
Non-alcoholic Fatty Liver Disease* / etiology