Restoration of calcium release synchrony: A novel target for heart failure and ventricular arrhythmia

Heart Rhythm. 2023 Dec;20(12):1773-1781. doi: 10.1016/j.hrthm.2023.08.040. Epub 2023 Sep 9.

Abstract

Myocardial calcium (Ca2+) signaling plays a crucial role in contractile function and membrane electrophysiology. An abnormal myocardial Ca2+ transient is linked to heart failure and ventricular arrhythmias. At the subcellular level, the synchronous release of Ca2+ sparks from sarcoplasmic Ca2+ release units determines the configuration and amplitude of the global Ca2+ transient. This narrative review evaluates the role of aberrant Ca2+ release synchrony in the pathophysiology of cardiomyopathies and ventricular arrhythmias. The potential therapeutic benefits of restoration of Ca2+ release synchrony in heart failure and ventricular arrhythmias are also discussed.

Keywords: Ca(2+) release synchrony; Calcium release unit; Calcium transient; Couplon; RyR2 stabilization.

Publication types

  • Review

MeSH terms

  • Arrhythmias, Cardiac
  • Calcium Signaling / physiology
  • Calcium* / metabolism
  • Heart Failure*
  • Humans
  • Myocardium / metabolism
  • Myocytes, Cardiac / metabolism
  • Ryanodine Receptor Calcium Release Channel / metabolism
  • Sarcoplasmic Reticulum / metabolism

Substances

  • Calcium
  • Ryanodine Receptor Calcium Release Channel