Cytotoxicity of a new spiro-acridine derivative: modulation of cellular antioxidant state and induction of cell cycle arrest and apoptosis in HCT-116 colorectal carcinoma

Naunyn Schmiedebergs Arch Pharmacol. 2024 Mar;397(3):1901-1913. doi: 10.1007/s00210-023-02686-0. Epub 2023 Sep 7.

¹ Postgraduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
² Drug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, João Pessoa, Paraíba, Brazil.
³ Federal University of Pernambuco, Recife, Pernambuco, Brazil.
⁴ Laboratory for Risk Assessment of Novel Technologies, Department of Molecular Biology, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
⁵ Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa , Paraíba, Brazil.
⁶ Postgraduation Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, João Pessoa, Paraíba, Brazil. mariannavbs@gmail.com.
⁷ Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa , Paraíba, Brazil. mariannavbs@gmail.com.

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